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PROF. ENGİN ORAL, MD

Obstetrics and Gynecology

E-Mail: hastane@biruni.edu.tr
Phone: 444 8 276

PROF. ENGİN ORAL, MD

Education

Bachelor of Medicine, Istanbul University, Faculty of Medicine, 1982-1988
Residency in Obstetrics and Gynecology, Istanbul University, Cerrahpasa Faculty of Medicine, 1988-1992
Postgraduate Training in Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, 1995-1996

Experience

Clinical Chief, Istanbul University Cerrahpasa Faculty of Medicine, Department of Obstetrics and Gynecology, 1993-1997
Associate Professor, Istanbul University Cerrahpasa Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, 1997-2003
Professor, Istanbul University Cerrahpasa Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, 2003-2019
Professor, Bezmialem Vakif University Faculty of Medicine, Department of Obstetrics and Gynecology, 2020-2022
Professor, Biruni University Faculty of Medicine, Department of Obstetrics and Gynecology, 2023-present

Scientific Memberships

• World Endometriosis Society (WES)
• European Endometriosis League (EEL)
• Asian Society of Endometriosis and Adenomyosis (ASEA)
• European Society of Human Reproduction and Embryology (ESHRE)
• American Society for Reproductive Medicine (ASRM)
• American Association of Gynaecologic Laparoscopists (AAGL)
• European Society for Gynaecological Endoscopy (ESGE)
• American College of Obstetricians and Gynecologists (ACOG) (Associate Membership International)
• European Menopause and Andropause Society (EMAS)
• International Menopause Society (IMS)

Scientific Publications

1.Darici E, Kemahlı MNC, Bahat PY, Yücel B, Oral E. Validation of the Turkish version of Endometriosis Health Profile questionnaire (EHP-30) to evaluate the quality of life in women with
endometriosis. Facts Views Vis Obgyn. 2023 Jun;15(2):131-136. doi:10.52054/FVVO. 15.2.
079.PMID: 37436049
2. Kaya C, Usta T, Oral E. Telemedicine and Artificial Intelligence in the Management of Endometriosis: Future Forecast Considering Current Progress. Geburtshilfe Frauenheilkd. 2022 Nov
29;83(1):116-117. doi: 10.1055/a-1950-6634
3. Kale A, Aboalhasan Y, Gündoğdu EC, Usta T, Oral E. Obturator nerve endometriosis: A systematic review of the literature. Facts Views Vis Obgyn. 2022 Sep;14(3):219-223. doi:
10.52054/FVVO.14.3.032.PMID: 36206796
4. Darici E, Salama M, Bokor A, Oral E, Dauser B, Hudelist G. Different segmental resection techniques and postoperative complications in patients with colorectal endometriosis: A systematic
review. Acta Obstet Gynecol Scand. 2022 Jul;101(7):705-718. doi: 10.1111/aogs.14379. Epub
2022 Jun 6.PMID: 35661342 Review.
5. Kale, A., Kuru, B., Baydili, K.N., Cokay, D., Basol, G., Cansu Gundogdu, E., Mat, E., Ertugrul,
I., Altuntas, Y.E., Usta, T. and Aboalhasan, Y., Oral E. Combination of laparoscopic side-toend colorectal anastomosis and vaginal nose (natural orifice specimen extraction) surgery for colorectal endometriosis: Technique and outcomes. Journal of Endometriosis and Pelvic Pain Disorders. 2022;14(3):149-157. doi:10.1177/22840265221095772
6. Kale A, Baydili KNS, Keles E, Gundogdu E, Usta T, Oral E. Comparison of Isolated Sciatic
Nerve and Sacral Nerve Root Endometriosis: A Review of the Literature. J Minim Invasive Gynecol. 2022 Aug;29(8):943-951. doi: 10.1016/j.jmig.2022.05.017. Epub 2022 May
29.PMID: 35649478 Review.
7. Yalçın Bahat P, Ayhan I, Üreyen Özdemir E, İnceboz Ü, Oral E. Dietary supplements for treatment of endometriosis: A review. Acta Biomed. 2022 Mar 14;93(1): e2022159. doi:
10.23750/abm.v93i1.11237
8. Usta T, Yilmaz S, Topbas Selcuki NF, Ayhan I, Kale A, Oral E. Surgical lysis of nerve entrapment caused by retroperitoneal fibrosis/adhesions; two case reports and a literature review Journal of Endometriosis and Pelvic Pain Disorders. 2021;13(4):284
287.doi:10.1177/22840265211058431
9. Mis C., Kofali G., Swift B., Yalcin Bahat P., Senocak G., Taneri B., Hummelshoj L., Missmer
A.S., Becker C., Zondervan K., Yuksel Ozgor B., Oral E., Inceboz U., Hocaoglu M. and
Rahmioglu N. Protocol for the Cultural Translation and Adaptation of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project Endometriosis Participant Questionnaire (EPHect). Front. Glob. Womens Health, 26 March 2021
https://doi.org/10.3389/fgwh.2021.644609
10. N.F.T.Topbas Selcuki, S.Yilmaz, C.Kaya, T.A.Usta, E.Oral. Thoracic Endometriosis: A Review Comparing 480 Patients Based on Catamenial and Non-Catamenial Presentation. November 2020Journal of Minimally Invasive Gynecology 27(7): S45 DOI:
10.1016/j.jmig.2020.08.374
11. Topçu HO, Kaya C, Oral E. Fertility issue in early stage endometrial cancer patients.
Translational Cancer Research. 2020;9(12):7797-808.
12. Yalçın Bahat P, Kaya C, Selçuki NFT, Polat İ, Usta T, Oral E. The COVID-19 pandemic and
patients with endometriosis: A survey-based study conducted in Turkey. Int J Gynaecol Obstet.
2020 Aug 4. doi: 10.1002/ijgo.13339.
13. Kaya C, Usta T, Baghaki HS, Oral E. Relation between educational reliability and viewer interest in YouTube® videos depicting endometrioma cystectomy surgical techniques. J Gynecol
Obstet Hum Reprod. 2020 May 16:101808. doi: 10.1016/j.jogoh.2020.101808.
14. Oral E, Sozen I, Uludag S, Demirkiran F, Ilvan S, Oncul M, Celik HG. The prevalence of endometrioma and associated malignant transformation in women over 40 years of age. J Gynecol
Obstet Hum Reprod. 2020 May;49(5):101725. doi: 10.1016/j.jogoh.2020.101725.
15. Parlatan U, Inanc MT, Ozgor BY, Oral E, Bastu E, Unlu MB, Basar G. Raman spectroscopy
as a non-invasive diagnostic technique for endometriosis. Sci Rep. 2019 Dec 24;9(1):19795. doi:
10.1038/s41598-019-56308-y.
16. Oral E, Inceboz U. How can we manage patients with endometriosis older than 40 years of
age? Minerva Med. 2019 Dec 11. doi: 10.23736/S0026-4806.19.06377-8.
17. Karacan T, Ozyurek E, Yesiralioglu S, Kiyak H, Usta T, Oral E. Endometriomas with low-risk
malignancy potential in ultrasonography with high human epididymis protein 4 and risk of
ovarian malignancy algorithm: a cases series, Gynecol Endocrinol., 2019 Aug 20:1-5, doi:
10.1080/09513590.2019.1653842.
18. Oral E, Toksoy G, Sofiyeva N, Celik HG, Karaman B, Basaran S, Azami A, Uyguner ZO.
Clinical and Genetic Investigation of Premature Ovarian Insufficiency Cases from Turkey. J
Gynecol Obstet Hum Reprod., 2019 Apr 23, pii: S2468-7847(18)30508-7. doi:
10.1016/j.jogoh.2019.04.007.
19. Oral E, Aydin O, Kumbak BA, İlvan S, Yilmaz H, Tustas E, Bese T, Demirkiran F, Arvas M.
Concomitant endometriosis in malignant and borderline ovarian tumours. J Obstet Gynaecol.,
2018 Nov.,38(8):1104-1109. doi: 10.1080/01443615.2018.1441815.
20. Usta T., Karacan T., Hanli U., Cansu E., Oral E. Hysteroscopic management of a juvenile
cystic adenomyosis, J Endometriozis and Pelvic Pain Disorders, 2018 Jun; vol10:123-123,
doi:org/10.1177/228402651877879.
21. Kaya C, Alay I, Guraslan H, Gedikbasi A, Ekin M, Ertaş Kaya S, Oral E, Yasar L. The Role
of Serum Caspase 3 Levels in Prediction of Endometriosis Severity. Gynecol Obstet Invest. 2018
Aug 2:1-10. doi: 10.1159/000489494.
22. Goksever Celik H, Karacan T, Kaya C, Uhri, M., Savkli, A. O., Yalcin Bahat, P., Altintas, T.,
Usta, T., Polat, I., Gorgen, H., Oral, E. Abdominal wall endometriosis: A monocentric continuous series and review of the literature. Journal of Endometriosis and Pelvic Pain Disorders.
2019;11(2):95-101. doi:10.1177/2284026519834465
23. Sofiyeva N, Oral E. Letter from original author re. Does telomerase activity have an effect on
infertility in patients with endometriosis? Methodological issues. Eur J Obstet Gynecol Reprod
Biol. 2017 Sep; 216:259-260. doi: 10.1016/j.ejogrb.2017.07.009.
24. Sofiyeva N, Ekizoglu S, Gezer A, Yilmaz H, Kolomuc Gayretli T, Buyru N, Oral E. Does telomerase activity have an effect on infertility in patients with endometriosis? Eur J Obstet Gynecol Reprod Biol. 2017 Jun; 213:116-122. doi: 10.1016/j.ejogrb.2017.04.027.
25. Oral E, Aydogan Mathyk B, Aydogan BI, Acıkgoz AS, Erenel H, Celik Acıoglu H, Anık Ilhan
G, Dane B, Ozel A, Tandogan B, Cakar E, Isci H, Kayan B, Aslan H, Ekiz A, Sancak S, Celik
A, Yoldemir T, Uzun O, Erdogan MF. Iodine status of pregnant women in a metropolitan city
which proved to be an iodine-sufficient area. Is mandatory salt iodisation enough for pregnant
women? Gynecol Endocrinol. 2016;32(3):188-92. doi: 10.3109/09513590.2015.1101443. Epub
2015 Oct 22.
26. Gezer A, Oral E. Progestin therapy in endometriosis. Womens Health (Lond). 2015
Aug;11(5):643-52. doi: 10.2217/whe.15.42. Epub 2015 Sep 21. Review.
27. Oral E, Demir B, Inceboz U. Endometriosis and ovarian reserve. Womens Health (Lond).
2015 Aug;11(5):671-5. doi: 10.2217/whe.15.53. Epub 2015 Sep 7. Review. Inceboz U, Oral E.
Foreword. Womens Health (Lond). 2015 Aug;11(5):575. doi: 10.2217/whe.15.61. Epub 2015
Sep 7.
28. Sahmay S, Usta TA, Zebitay G, Senturk LM, Oral E, Ocal P, Idil M, Irez T. Comparison of
follitropin alfa and urinary gonadotropins in IVF cycles. Minerva Ginecol. 2014 Aug;66(4):341-
6.
29. Elter K, Oral E. Surgical treatment before assisted reproductive technologies. Semin Reprod
Med. 2014 Jul;32(4):253-61. doi: 10.1055/s-0034-1375177. Epub 2014 Jun 11. Review.
30. Findikli N, Oral E. Time-lapse embryo imaging technology: does it improve the clinical results?
Curr Opin Obstet Gynecol. 2014 Jun;26(3):138-44. doi: 10.1097/ GCO.0000000000000072.
Review.
31. Tuten A, Kucur M, Imamoglu M, Oncul M, Acikgoz AS, Sofiyeva N, Ozturk Z, Kaya B, Oral
E. Serum YKL-40 levels are altered in endometriosis. Gynecol Endocrinol. 2014
May;30(5):381-4. doi: 10.3109/09513590.2014.887671. Epub 2014 Feb 17.
32. Sahmay S, Guralp O, Aydogan B, Cepni I, Oral E, Irez T. Anti-Mullerian hormone and polycystic ovary syndrome: assessment of the clinical pregnancy rates in in vitro fertilization patients.
Gynecol Endocrinol. 2013 May;29(5):440-3. doi: 10.3109/09513590.2013.769519. Epub 2013
Mar 6.
33. Irez T, Usta TA, Zebitay G, Oral E, Senol H, Sahmay S. Evaluation of subgroups of the human sperm hypoosmotic swelling test in normozoospermic male cases with recurrent fertilization failure: a prospective case-controlled study. Arch Gynecol Obstet. 2013 Apr;287(4):797-
801. doi: 10.1007/s00404-012-2634-6. Epub 2012 Nov 18.
34. Kumbak B, Oral E, Bukulmez O. Female obesity and assisted reproductive technologies.
Semin Reprod Med. 2012 Dec;30(6):507-16. doi: 10.1055/s-0032-1328879. Epub 2012 Oct 16.
Review.
35. Sahmay S, Demirayak G, Guralp O, Ocal P, Senturk LM, Oral E, Irez T. Serum anti-mullerian hormone, follicle stimulating hormone and antral follicle count measurement cannot predict
pregnancy rates in IVF/ICSI cycles. J Assist Reprod Genet. 2012 Jul;29(7):589-95.
doi:10.1007/s10815-012-9754-6. Epub 2012 Apr 11.
36. Usta T, Oral E. Is the measurement of anti-Mullerian hormone essential? Curr Opin Obstet
Gynecol. 2012 Jun;24(3):151-7. doi: 10.1097/GCO.0b013e3283527dcf. Review.
37. Yoldemir T, Oral E. Has fertility declined in recent decades? Curr Opin Obstet Gynecol. 2012
Jun;24(3):119-26. doi: 10.1097/GCO.0b013e32835213f1. Review.
38. Kucuk M, Halil S, Ocer F, Oral E. Labial fusion first diagnosed during pregnancy with voiding
difficulty and its management: a case report. Clin Exp Obstet Gynecol. 2011;38(1):94-5.
39. Cetinkaya F, Gelen SA, Kervancioglu E, Oral E. Prevalence of asthma and other allergic diseases in children born after in vitro fertilisation. Allergol Immunopathol (Madr). 2009 JanFeb;37(1):11-3.
40. Kumbak B, Oral E. Quality of residual follicles may depend on the etiology of “declining”
ovarian function? Fertil Steril. 2007 Nov;88(5):1480-1; author reply 1481.
41. Oral E, Elter K. The impact of cesarean birth on subsequent fertility. Curr Opin Obstet Gynecol. 2007 Jun;19(3):238-43. Review.
42. Kumbak B, Oral E, Karlikaya G, Lacin S, Kahraman S. Serum estradiol and beta- HCG
measurements after day 3 or 5 embryo transfers in interpreting pregnancy outcome. Reprod Biomed Online. 2006 Oct;13(4):459-64.
43. Kumbak B, Oral E, Kahraman S, Karlikaya G, Karagozoglu H. Young patients with diminished ovarian reserve undergoing assisted reproductive treatments: a preliminary report. Reprod
Biomed Online. 2005 Sep;11(3):294-9.
44. Oral E, Genç MR. Hormonal monitoring of the first trimester of pregnancy. Obstet Gynecol
Clin North Am. 2004 Dec;31(4):767-78, x. Review.
45. Aksu F, Gezer A., Oral E., Seventeen-year review of hysterectomy procedures in a university
clinic in Istanbul (1985-2001) rch Obstet Gynecol, 2004.
46. Oral E, Ilvan S, Tustas E, Korbeyli B, Kosebay D, Prevalence of endometriosis in malignant
epithelial ovary tumours Research article Eur J Obstet Gynecol Reprod Biol. 2003
Jul;109(1):97-101.
47. Oral E, Gezer A, Cagdas A, Pakkal N. Oxytocin Infusion in Labor: the effect different indications and the use of different diluents on neonatal bilirubin levels. Arch Gynecol Obstet. 2003
Jan;267(3):117-20.
48. Oral E, Yetis O, Elibol F, Senol H, Irez T, Aksu FM. Assessment of human sperm morphology
by strict criteria: comparison of wet preparation versus stained with the modified Diff-Quik
method. Arch Androl. 2002 Jul-Aug;48(4):307-14.
49. Oral E, Cağdaş A, Gezer A, Kaleli S, Öçer F, Perinatal and Maternal Outcomes of Fetal Macrosomia. Eur J Obstet Gynecol Reprod Biol. 2001 Dec; 99(2): 167-171.
50. Oral E, Cağdaş A, Gezer A, Kaleli S, Aydin Y, Oçer F. Hematological abnormalities in adolescent menorrhagia. Arch Gynecol Obstet. 2002 Apr;266(2):72-4.
51. Erel CT, Oral E, Senturk LM, Aksu MF. Craniopharyngioma and Bardet-Biedl syndrome. A
case report. J Reprod Med. 2001 May;46(5):501-3.
52. Akçay T, Dinçer Y, Kayali R, Colgar U, Oral E, Cakatay U. Effects of hormone replacement
therapy on lipid peroxides and oxidation system in postmenopausal women. J Toxicol Environ
Health A. 2000 Jan 14;59(1):1-5.
53. Sahmay S, Kaleli S, Oral E, Alper T, Unal O, Karacan I, Atasu T. Effect of different types of
intrauterine devices on intrauterine activity. Int J Fertil Womens Med. 1999 May-Jun;44(3):150-
5.
54. Öçer F, Kaleli S, Budak E, Oral E. Fetal Weight Estimation and Prediction of Fetal Macrosomia in Nondiabetic Pregnant Women Research article. Eur J Obstet Gynecol Reprod
Biol.1999 Mar; 83(1):47-52.
55. Erel CT, Senturk LM, Oral E, Mutlu H, Colgar U, Seyisoglu H, Ertungealp E. Results of the
ACTH stimulation test in hirsute women. J Reprod Med. 1999 Mar; 44(3):247-52.
56. Bahtiyar MO, Seli E, Oral E, Senturk LM, Zreik TG, Arici A. Follicular fluid of women with
endometriosis stimulates the proliferation of endometrial stromal cells. Hum Reprod. 1998
Dec;13(12):3492-5.
57. Kaleli S, Erel CT, Oral E, Elter K, Akman C, Colgar U. Ovarian stromal hypertrophy in polycystic ovary syndrome. J Reprod Med. 1998 Oct;43(10):893-7.
58. Erel CT, Senturk LM, Oral E, Colgar U, Ertungealp E. Adrenal androgenic response to 2-
hour ACTH stimulation test in women with PCOS. Gynecol Endocrinol. 1998 Aug;12(4):223-9.
59. Zeyneloglu HB, Senturk LM, Seli E, Oral E, Olive DL, Arici A. The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation. Hum Reprod. 1998 May;13(5):1194-9.
60. Arici A, Seli E, Senturk L,Gutierrez L, Oral E, Taylor H, Interleukin-8 in the Human Endometrium The Journal of Clinical Endocrinology & Metabolism, Volume 83, Issue 5, 1 May
1998, Pages 1783–1787.
61. Arici A, Seli E, Zeyneloglu HB, Senturk LM, Oral E, Olive DL. Interleukin-8 induces proliferation of endometrial stromal cells: a potential autocrine growth factor. J Clin Endocrinol Metab.
1998 Apr;83(4):1201-5.
62. Oral E, Seli E, Bahtiyar MO, Jones EE, Arici A. Growth-regulated alpha expression in human
preovulatory follicles and ovarian cells. Am J Reprod Immunol. 1997 Jul; 38(1):19-25.
63. Arici A, Oral E, Attar E, Tazuke S, Olive D. Monocyte chemotactic protein-1 concentration in
peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial
cells Research article Fertil Steril. 1997 Jun; 67(6):1065-72.
64. Arici A, Oral E, Bahtiyar O, Engin O, Seli E, Jones EE. Leukaemia inhibitory factor expression in human follicular fluid and ovarian cells. Hum Reprod. 1997 Jun;12(6):1233-9.
65. Oral E, Arici A. Pathogenesis of Endometriosis, Research article Obstetrics and Gynecology
Clinics of North America, 1997 Jun; 24(2): 219-233.
66. Arici A, Oral E, Bukulmez O, Buradagunta S, Bahtiyar O, Jones EE. Monocyte chemotactic
protein-1 expression in human preovulatory follicles and ovarian cells. J Reprod Immunol. 1997
Feb;32(3):201-19.
67. Oral E, Seli E, Bahtiyar MO, Olive DL, Arici A Growth-regulated alpha expression in the peritoneal environment with endometriosis. Obstet Gynecol. 1996 Dec;88(6): 1050-6.
68. Erel CT, Kaleli S, Oral E, Engür A, Eren T, Calay Z, Aydinli K. DNA ploidy of ectopic pregnancy and first trimester spontaneous abortion investigated by flow cytometry. Acta Obstet Gynecol Scand. 1996 Nov;75(10):881-5.
69. Oral E, Arici A, Olive D, Huszar G. Peritoneal fluid from women with moderate or severe endometriosis inhibits sperm motility: the role of seminal fluid components Research article Fertil
Steril. 1996 Nov; 66(5):787-792.
70. Arici A, Oral E, Bukulmez O, Buradagunta S, Engin O, Olive DL. Interleukin-8 expression
and modulation in human preovulatory follicles and ovarian cells. Endocrinology. 1996
Sep;137(9):3762-9.
71. Oral E, Olive DL, Arici A. The peritoneal environment in endometriosis. Hum Reprod Update. 1996;2(5):385-398.
72. Oral E, Arici A. Peritoneal growth factors and endometriosis Semin Reprod Endocrinol.
1996;14(3):257-67.
73. Arici A, Oral E, Bukulmez O, Duleba A, Jones E The effect of endometriosis on implantation:
results from the Yale University in vitro fertilization and embryo transfer program Research article Fertil Steril. 1996 Mar; 65(3): 603-607.
74. Sahmay S, Oral E, Saridogan E, Senturk L, Atasu T. Endometrial biopsy findings in infertility:
analysis of 12,949 cases. Int J Fertil Menopausal Stud. 1995 Nov-Dec; 40(6):316-21.
ULUSLARARASI KİTAP YAZARLIĞI
1. Endometriosis and Adenomyosis: Global Perspectives Across the Lifespan; Springer International Publishing; 2022; ISBN978-3-030-97236-3

Medical Fields of Interest

ÜREME ENDOKRİNOLOJİSİ
ENDOMETRİOZİS
POLİKİSTİK OVER SENDROMU
KONTRASEPSİYON
MENAPOZ
İNFERTİLİTE (KISIRLIK)
TÜP BEBEK (IVF)
ENDOSKOPİK CERRAHİ
LAPAROSKOPİ
HİSTEROSKOPİ

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